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Surabhi 2000 Kannada Software 52

Surabhi 2000 Kannada Software 52



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Surabhi 2000 Kannada Software 52


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Friday, May 30, 2008

The Geography Of Genetic Predisposition

In this post I'll be talking about some preliminary results which I got using a case-control study design. The title pretty much says it all, the cases are individuals that, at some point in their life, were diagnosed with schizophrenia, and the controls are healthy relatives that did not develop the disease. The main question that I want to answer is whether there is a specific "micro-geographical" effect in the sense that the areas with "higher schizophrenia rates" are also those areas with "higher schizophrenia heritabilities".

I'll also add a link to a new post in the "Geography Of Alcoholism" blog where I'll discuss the same subject in the case of another mental disorder - bipolar disorder.

My preliminary study is the first of the three phases of a different project. In this post, I'll be discussing the heritability of schizophrenia, the simplest possible model, i.e. a case-control design (in this case schizophrenia is "diseased", and the control are "healthy"). The second post will deal with the heritability of bipolar disorder (bipolar is "diseased", and the control is a "non-ill" person), while the third post will deal with the geographic distribution of the genes responsible for major mental disorders.

In order to set the stage for this discussion, let me add that my study is a cross-sectional study. I downloaded the covariates for several counties in the United States and grouped the counties into "types". These are counties which, according to the Census Bureau statistics, differ, by a wide margin, in the percentage of individuals with mental illness (see the figure above). I used a split-sample procedure in a case-control study. For each county, the "cases" were the 10% of individuals with the highest rate

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